KMID : 1138520180210020082
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Journal of Pharmacopuncture 2018 Volume.21 No. 2 p.82 ~ p.89
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Antiglycation and antioxidant activity of four Iranian medical plant extracts
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Safari Mohammad Reza
Azizi Omid Heidary Somayeh Sadat Kheiripour Nejat Ravan Alireza Pouyandeh
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Abstract
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Objective:Diabetes mellitus (DM) is the most common metabolic disorder that defined by chronic hyperglycemia for the deficiency in insulin secretion or resistance. Hyperglycemia could induce non-enzymatic glycation of proteins. It has been suggested that some traditional plants can improve blood glucose and inhibit glycation process. This work evaluates and compares the anti-glycation activities of four Iranian plant extracts in vitro.
Methods:The methanolic extract of ¡°Fumaria officinalis, Stachys lavandulifolia, Salvia hydrangea and Rosa Damascene¡± was prepared in three different concentrations. Phenolic, flavonoids content and antioxidant activity were evaluated. The multistage glycation markers- fructosamines (early stage), protein carbonyls (intermediate stage) and ¥â aggregation of albumin were investigated in the bovine serum albumin (BSA)/ glucose systemt.
Results:All plants showed the high potency of scavenging free radicals and glycation inhibition in the following order: Fumaria officinalis> Rosa Damascene> Stachys lavandulifolia > Salvia hydrangea. There was a significant correlation between antioxidant and anti-glycation activity. Also, the antioxidant and anti-glycation capacity of extracts correlated with total phenolic and flavonoids content.
Conclusion:Our findings demonstrated that the studied plants are good sources of anti-glycation and antioxidant compounds and, these properties can primarily attributable to phenolics, particularly flavonoids.
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KEYWORD
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Diabetes mellitus, Glycosylation, Antioxidants
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